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Caffeic Acid From propolis

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CAS No. 115610-29-2

Active Ingredient: Caffeic Acid Phenethyl Ester

Specification: 10~99%

Test Method HPLC

Synonyms: 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester, (E)-; CAPE; Caffeic Acid Phenethyl Ester
Molecular formula: C17H16O4 
Molecular weight: 284.3 
CAS No.: 115610-29-2
Melt Point: 128.0C to: 129.0C 
Solubility: Soluble in DMSO, 100% ethanol, methanol, acetone or acetonitrile; insoluble in water.
Appearance: White to off-white crystalline solid.
Color: White 

Beneficial Uses

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have

  1. Anti-mitogenic,
  2. Anti-carcinogenic,
  3. Anti-inflammatory, 
  4. Anti-cancer
  5. Immunomodulatory properties.
  6. A potent and specific inhibitor of the activation of nuclear transcription factor NF-KB. It is also exhibits inhibitory activity against HIV-1 integrase with IC50 of 7uM.

Functional of propolis

Propolis is marketed by health food stores as a traditional medicine, and for its claimed beneficial effect on human health.

SNatural medicine practitioners often utilize propolis for the relief of various conditions, including inflammations, viral diseases, ulcers, superficial burns or scalds. Some such therapies are based on the traditional practices of Traditional Chinese Medicine, ayurveda or homeopathy. Propolis is also believed to promote heart health and reduce the chances of cataracts.Old beekeepers recommend a piece of propolis kept in the mouth as a remedy for a sore throat. Propolis lozenges can be bought in France.

Though claims have been made for its use in treating allergies, propolis may cause severe allergic reactions if the user is sensitive to bees or bee products. 

Few of these folkloric claims have been clinically evaluated at the level of large-scale, randomized, double-blind studies.

Some in-vitro or rat-model studies are available in published biomedical literature. The composition of propolis is variable, depending on season, bee species and geographic location, so caution must be applied in extrapolating results(below).

Depending upon its precise composition propolis may show powerful local antibiotic and antifungal properties. Studies indicate that it may be effective in treating skin burns. Propolis also exhibits immunomodulatory effects.

Propolis has attracted the attention of the dental community, although there is currently no conclusive evidence to support the argument that propolis actively protects against caries and other forms of oral disease.

Propolis can also be used to treat canker sores, and its use in canal debridement for endodontic procedures has been explored in Brazil.

Anti-microbial activity of propolis:

Bacterial effects of Propolis for Upper Respiratory Infections:

Anti-oxidant activity of Propolis:

Antibacterial effect of Propolis on Oral Bacteria & Dental Plaque:

Protective action of Propolis on Cartilage:

Why Organic Herb Inc. CAPE:
  • A.) Organic Herb Inc. CAPE is 100% extracted from natural Propolis has been had in daily life for at least 4,500 years, very safe and more bioactive.
  • B.) Organic Herb Inc. have the most purity CAPE, Our CAPE is a 99% purity product tested by HPLC and just one peak on HPLC chromatogram.
  • C.) Organic Herb Inc. CAPE almost have no unpleasant taste compare to other CAPE and it can be easier to take by oral.
  • D.) Organic Herb Inc. offer CAPE at a very lower price with a very high and uniform quality.
  • E.) More important --- we have a very large output to meet our customers’ big and continual orders
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